Oxysterols recruit tumor-supporting neutrophils within the tumor microenvironment

نویسندگان

  • Laura Raccosta
  • Raffaella Fontana
  • Catia Traversari
  • Vincenzo Russo
چکیده

By binding to the liver X receptor (LXR), oxysterols inhibit the expression of chemokine (C-C motif) receptor 7 (CCR7), hence impairing the migration of dendritic cells to secondary lymphoid organs and inhibiting antitumor immune responses. We have recently identified a new tumor-supporting activity of oxysterols, which recruit neutrophils within tumor microenvironment by a chemokine (C-X-C motif) receptor 2 (CXCR2)-dependent, LXR-independent mechanism.

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عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2013